g

p

p

or the gene ELOVL5. The target DEG named as ELOVL5 with

ion number ILMN_1712533 was located at zero degree at the

d. Although different models generated different ranking

ce spectra, the pattern of the spectra was consistent that many

nt contributing methylation sites were not clustered near the point

degree for this DEG. Instead, many significant contributing

on sites were far away from the point of zero degree for this DEG.

The ranking importance spectra of the four M2E models for the gene EVOVL5

session number ILMN_1712533. From outside to inside, they are the RLR

Lasso model, the SVM model and the random forest model. All ranking

values have been normalised.

es 4.34(a) and (b) show the Lasso and RLR models constructed

target DEG EVOVL5. They detailed how the differential

on profiles of the remote methylation sites contributed to the

al expression profile of EVOVL5. Taking the Lasso model as an

two most contributing methylation sites had at least 11 mega

ay from EVOVL5. The differential methylation of these two

on sites all had a negative relationship with the differential

n profile of EVOVL5. A methylation site that had its differential